P8 DEFICIENCY LEADS TO ELEVATED PANCREATIC BETA CELL MASS BUT DOES NOT CONTRIBUTE TO INSULIN RESISTANCE IN MICE FED WITH HIGH-FAT DIET.

p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet.

BACKGROUND:p8 was initially described as being overexpressed in Door Latch Pushrod acute pancreatitis and encoding a ubiquitous stress protein.Analysis of insulin sensitivity and glucose tolerance in p8-knockout and haplodeficient mice revealed counterintuitive results.Thus, we determined glycemic control of p8 in mice fed with standard (SD) and hi

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Electrical stimulation of chicken embryo development supports the Inside story scenario of human development and evolution

Abstract Animal evolution is driven by random mutations at the genome level.However, it has long been suggested that there exist physical constraints which limit the set of possible outcomes.In craniate evolution, it has been observed that head features, notably in the genus homo, can be ordered in a morphological diagram such that, as the brain ex

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